Hazard ratios (HRs) for incident dementia were defined with Cox proportional hazard regression models in which beverage intake was fitted as penalized cubic splines. Over 4.2 million person-years, 4270 dementia cases occurred in 351,436 UK Biobank participants. The present study analyses the association of alcohol intake from wine and non-wine alcoholic beverages (non-wine) in g/d, as well as coffee and tea in cups/d, with incident dementia. The prevalence of dementia is increasing globally and is linked to obesity and unfavorable dietary habits. VD, vascular dementia Con, control Res, resveratrol Bcl-2, B-cell lymphoma 2 Bax, Bcl-2-like protein 4. However, hippocampal caspase-3 protein expression was significantly decreased after 4 weeks of resveratrol treatment. Compared with that in the Con group, the expression of caspase-3 in the VD group was significantly increased. (D) The relative protein expression of caspase-3. However, hippocampal Bax protein expression was significantly decreased after 4 weeks of resveratrol treatment. Compared with that in the Con group, the expression of Bax in the VD group was significantly increased. (C) The relative protein expression of Bax. Compared with that in the VD group, the expression of Bcl-2 in the Res group was significantly increased. Compared with that in the Con group, the expression of Bcl-2 in the VD group was significantly decreased. (B) The relative protein expression of Bcl-2. (A) Bcl-2, Bax, caspase-3 and β-actin protein bands. Western blot analysis of Bcl-2, Bax and caspase-3 expression.
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